If you feed coffee to rats you will, maybe, want to drink in some or all of the info in this study, which involved feeding coffee to rats, and which poses intellectual challenges of many sorts:
“The Relationship between Coffee-Related Factors and Cortical and Hippocampal Structure: A Triangulation of Evidence Approach and Mendelian Randomization Research,” Zining Luo, Lijun Xiong, Xinyu Xu, Meng Sun, Yingfei Mu, Hongjie Chen, Zhenglong Liu, Zhiyong Luo, Jianli Wang, and Ying Liu, Frontiers in Nutrition, vol. 11, 2024, article 1351067.
The authors explain:
“Existing studies have reported sustained changes in the cortical structure of rats due to coffee-related factors, which are speculated to occur in the human body. However, there is a lack of research on this topic. Additionally, previous observational studies have found the impact of diseases on cortical structure and the potential therapeutic effects of coffee on these diseases. Our aim was to study the causal effects of coffee-related factors on the human brain using SNPs (single nucleotide polymorphisms). We will connect these discovered causal effects to the impact of diseases on the brain. Through triangulating evidence, we will reveal the potential active areas of coffee in preventing diseases.”